From the North

Hutchinson River Parkway, Bronx River Parkway or Spain Brook Parkway: take the Cross County Parkway west.  Option to connect to 87 South (NY State Thruway) for the East side or continue West to the Henry Hudson Parkway (9A) for the West Side.

Interstate 95: entering from the Bronx at 178th Street for FDR Drive (for the East Side) or Westside Highway (West Side side of Manhattan)

From the East (Queens)

Triborough Bridge: Interstate 87 entering from Queens over the Triborough Bridge at 125th Street, with connection to the FDR Drive.

Midtown Tunnel: 495 (Long Island Expressway) to Midtown Tunnel at 40th Street & FDR Drive (Midtown / East Side)

From the East (Brooklyn)

Williamsburg Bridge (Brooklyn): Delancey Street (Downtown / East Side)

Manhattan Bridge (Brooklyn):- FDR Drive (Downtown / East Side).   South on the FDR will connect to the West Side Highway.

Brooklyn Bridge (Brooklyn):  FDR Drive (Downtown / East Side). South on the FDR will connect to 9A / West Side Highway heading north.

Battery Tunnel:  9A / West Side Highway (West Side) at Morris Street.  South on 9A will connect to the FDR heading north.

From the West (New Jersey)

Lincoln Tunnel (New Jersey):   40th Street & Twelfth Avenue (Midtown / West Side)

Holland Tunnel (New Jersey):  Canal Street (Downtown / West Side)